Publications

2026

Chen, G.; Wang, H.; Straus, S.; Li, H. The Minimal Folding Motif of the Repeat-in-Toxin Domain of Adenylate Cyclase ToxinLangmuir 2026, 42, 4, 3584-3593.

2025

Li, H.; Bian, Q. Stimuli-responsive protein hydrogels: From dynamic tuning of hydrogel mechanics to shape morphingSupramolecular Materials 2025, 100120.

Bian, Q.; Li, H. Fully Reshapeable and Recyclable Protein HydrogelsADVANCED MATERIALS 2025, 37(42), e09812.

Fu, L. ; Li, H. Ionic Crosslinking Improves the Stiffness and Toughness of Protein HydrogelsPolymer Science & Technology 2025, 1(4), 342-350.

Zuo, J.; Li. H. Intermolecular Misfolding Captured in Parallelly Organized TitinJournal of the American Chemical Society, 2025, 147(6), 4853-4861.

2024

Gao, X. ; Chen, Y. ; Li, H. ; Hu, C. Measurement Of Rotated Janus Particle’s Position And Orientation In The Optical Trap. NANOTECHNOLOGY AND PRECISION ENGINEERING 2024, 7, 043001.

Li, P. ; Li, H. A Handle-Free, All-Protein-Based Optical Tweezers Method To Probe Protein Folding-Unfolding Dynamics. Langmuir 2024, 40, 13721-13727.

Liu, X. ; Yao, R. ; Sun, Z. ; Zhang, H. ; Yan, F. ; Li, H. ; Zhang, W. Single-Molecule Study Reveals Ion-Dependent Conformational Change And Nanomechanical Property Of Crown Ether-Based Polymer. Macromolecules 2024, 57, 3798-3806.

Tubiana, L. ; Alexander, G. P. ; Barbensi, A. ; Buck, D. ; Cartwright, J. H. E. ; Chwastyk, M. ; Cieplak, M. ; Coluzza, I. ; Copar, S. ; Craik, D. J. ; Di Stefano, M. ; Everaers, R. ; Faisca, P. F. N. ; Ferrari, F. ; Giacometti, A. ; Goundaroulis, D. ; Haglund, E. ; Hou, Y. – M. ; Ilieva, N. ; Jackson, S. E. ; Japaridze, A. ; Kaplan, N. ; Klotz, A. R. ; Li, H. ; Likos, C. N. ; Locatelli, E. ; Lopez-Leon, T. ; Machon, T. ; Micheletti, C. ; Michieletto, D. ; Niemi, A. ; Niemyska, W. ; Niewieczerzal, S. ; Nitti, F. ; Orlandini, E. ; Pasquali, S. ; Perlinska, A. P. ; Podgornik, R. ; Potestio, R. ; Pugno, N. M. ; Ravnik, M. ; Ricca, R. ; Rohwer, C. M. ; Rosa, A. ; Smrek, J. ; Souslov, A. ; Stasiak, A. ; Steer, D. ; Sulkowska, J. ; Sulkowski, P. ; Sumners, D. Witt L. ; Svaneborg, C. ; Szymczak, P. ; Tarenzi, T. ; Travasso, R. ; Virnau, P. ; Vlassopoulos, D. ; Ziherl, P. ; Zumer, S. Topology In Soft And Biological Matter. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS 2024, 1075, 1-137.

Bian, Q. ; Kong, N. ; Arslan, S. ; Li, H. Calmodulin-Based Dynamic Protein Hydrogels With Three Distinct Mechanical Stiffness. ADVANCED FUNCTIONAL MATERIALS 2024, 34.

Lei, J. ; Li, H. The Photocleavable Protein Phocl-Based Dynamic Hydrogels. ACS BIOMATERIALS SCIENCE & ENGINEERING 2024, 10, 7404-7412

2023

Wang, H.; Miao, X.; Zhai, C.; Chen, Y.; Lin, Z.; Zhou, X.; Guo, M.; Chai, Z.; Wang, R.; Shen, W.; Li, H.; Hu, C. Mechanistic Insights into the Folding Mechanism of Region v in Ice-Binding Protein Secreted by Marinomonas Primoryensis Revealed by Single-Molecule Force Spectroscopy. Langmuir 2023, 39 (45), 16128–16137.

Chen, G.; Wang, H.; Bumba, L.; Jiří Mašín; Šebo, P.; Li, H. The Adenylate Cyclase Toxin RTX Domain Follows a Series Templated Folding Mechanism with Implications for Toxin Activity. Journal of Biological Chemistry 2023, 299 (9), 105150–105150.

Fu, L.; Li, L.; Bian, Q.; Xue, B.; Jin, J.; Li, J.; Cao, Y.; Jiang, Q.; Li, H. Cartilage-like Protein Hydrogels Engineered via Entanglement. Nature 2023, 618 (7966), 740–747.

Zuo, J.; Chen, H.; Li, H. Two Molecule Force Spectroscopy on Ligand-Receptor Interactions. Nanoscale 2023, 15 (41), 16581–16589.

Li, H. Single Molecule Force Spectroscopy Studies on Metalloproteins: Opportunities and Challenges. Langmuir 2023, 39 (4), 1345–1353.

Zuo, J.; Li, H. Two-Molecule Force Spectroscopy on Proteins. ACS Nano 2023, 17 (8), 7872–7880.

2022

Liu, J.; Guo, H.; Gao, Q.; Li, H.; An, Z.; Zhang, W. Coil–Globule Transition of a Water-Soluble Polymer. Macromolecules 2022, 55 (19), 8524–8532.

Duan, T.; Bian, Q.; Li, H. Protein Hydrogels with Reversibly Patterned Multidimensional Fluorescent Images for Information Storage. Biomacromolecules 2022, 23 (7), 3009–3016.

Wang, H.; Chen, G.; Li, H. Templated Folding of the RTX Domain of the Bacterial Toxin Adenylate Cyclase Revealed by Single Molecule Force Spectroscopy. Nature Communications 2022, 13 (1).

Gao, X.; Zhai, C.; Lin, Z.; Chen, Y.; Li, H.; Hu, C. Simulation and Experiment of the Trapping Trajectory for Janus Particles in Linearly Polarized Optical Traps. Micromachines 2022, 13 (4), 608.

Bian, Q.; Fu, L.; Li, H. Engineering Shape Memory and Morphing Protein Hydrogels Based on Protein Unfolding and Folding. Nature Communications 2022, 13 (1).

Xia, J.; Zuo, J.; Li, H. Molecular Homogeneity of GB1 Revealed by Single Molecule Force Spectroscopy. Nanoscale 2022, 14 (27), 9925–9931

Li, J.; Li, H. New Insights into the Folding–Unfolding Mechanism and Conformations of Cytochrome C. Chemical Science 2022, 13 (25), 7498–7508.

2021

Zuo, J. ; Zhan, D. ; Xia, J. ; Li, H. Single-Molecule Force Spectroscopy Studies Of Missense Titin Mutations That Are Likely Causing Cardiomyopathy. LANGMUIR 2021, 37, 12128-12137.

Li, J. ; Chen, G. ; Guo, Y. ; Wang, H. ; Li, H. Single Molecule Force Spectroscopy Reveals The Context Dependent Folding Pathway Of The C-Terminal Fragment Of Top7. CHEMICAL SCIENCE 2021, 12, 2876-2884.

Duan, T. ; Bian, Q. ; Li, H. Light-Responsive Dynamic Protein Hydrogels Based On Lovtrap. LANGMUIR 2021, 37, 10214-10222.

Li, H. There Is Plenty Of Room In The Folded Globular Proteins: Tandem Modular Elastomeric Proteins Offer New Opportunities In Engineering Protein-Based Biomaterials. ADVANCED NANOBIOMED RESEARCH 2021, 1, 2100028.

Zhai, C. ; Hu, C. ; Li, S. ; Ma, Y. ; Zhang, Y. ; Guo, T. ; Li, H. ; Hu, X. The Formation Principle Of Micro-Droplets Induced By Using Optical Tweezers. NANOSCALE ADVANCES 2021, 3, 279-286.

Wang, R. ; Liu, M. ; Wang, H. ; Xia, J. ; Li, H. Gb Tags: Small Covalent Peptide Tags Based On Protein Fragment Reconstitution. BIOCONJUGATE CHEMISTRY 2021, 32, 1926-1934.

2020

Wang, H. ; Li, H. Mechanically Tightening, Untying And Retying A Protein Trefoil Knot By Single-Molecule Force Spectroscopy. CHEMICAL SCIENCE 2020, 11, 12512-12521.

Li, J. ; Li, H. Single Molecule Force Spectroscopy Reveals That A Two-Coordinate Ferric Site Is Critical For The Folding Of Holo-Rubredoxin. NANOSCALE 2020, 12, 22564-22573.

Fu, L. ; Li, H. Toward Quantitative Prediction Of The Mechanical Properties Of Tandem Modular Elastomeric Protein-Based Hydrogels. MACROMOLECULES 2020, 53, 4704-4710.

Ma, G. ; Hu, C. ; Li, S. ; Gao, X. ; Li, H. ; Hu, X. Axial Displacement Calibration And Tracking Of Optically Trapped Beads. OPTICS AND LASERS IN ENGINEERING 2020, 134, 106285.

Fu, L. ; Li, H. Toward Quantitative Prediction Of The Mechanical Properties Of Tandem Modular Elastomeric Protein-Based Hydrogels. MACROMOLECULES 2020, 53, 4704-4710.

Duan, T. ; Li, H. In Situ Phase Transition Of Elastin-Like Polypeptide Chains Regulates Thermoresponsive Properties Of Elastomeric Protein-Based Hydrogels. BIOMACROMOLECULES 2020, 21, 2258-2267.

Gao, X. ; Wang, Y. ; He, X. ; Xu, M. ; Zhu, J. ; Hu, X. ; Hu, X. ; Li, H. ; Hu, C. Angular Trapping Of Spherical Janus Particles. SMALL METHODS 2020, 4, 2000565.

Wang, Y. ; Wang, H. ; Tran, M. V. ; W. Algar, R. ; Li, H. Yellow Fluorescent Protein-Based Label-Free Tension Sensors For Monitoring Integrin Tension. CHEMICAL COMMUNICATIONS 2020, 56, 5556-5559.

Teixeira, M. H. ; Curtolo, F. ; Camilo, S. R. G. ; Field, M. J. ; Zheng, P. ; Li, H. ; Arantes, G. M. Modeling The Hydrolysis Of Iron-Sulfur Clusters. JOURNAL OF CHEMICAL INFORMATION AND MODELING 2020, 60, 653-660.

Mehlich, A. ; Fang, J. ; Pelz, B. ; Li, H. ; Stigler, J. Slow Transition Path Times Reveal A Complex Folding Barrier In A Designed Protein. FRONTIERS IN CHEMISTRY 2020, 8, 587824.

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